Citation

Millogo GRC, Kologo JK, Kinda G, Yaméogo NV, Tougma JB, Kambiré Y, Thiam AT, Sanon B, Toguyeni JY, Samadoulougou A, Zabsonré P. Pan. Afr. Med. J. 2018; 29: 135.

Vernacular Title

Les accidents du traitement anticoagulant dans le Service de Cardiologie du Centre Hospitalier Universitaire Yalgado Ouedraogo de Ouagadougou (Burkina Faso).

Affiliation

UFR/SDS (Unité de Formation et de Recherche en Science de la Santé), Service de Cardiologie du CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso.

Copyright

(Copyright © 2018, African Field Epidemiology Network)

DOI

10.11604/pamj.2018.29.135.10650

PMID

30050599

PMCID

PMC6057581

Abstract

This study aimed to evaluate the profile of patients hospitalized for anticoagulant-induced hemorrhage. We conducted a retrospective, descriptive study within the Department of Cardiology at the Yalgado Ouedraogo Teaching Hospital, in Ouagadougou, over a period of 2 years from 1 January 2007 to 31 December 2008. All hospitalized patients with anticoagulant-induced hemorrhage were included in the study. The average age of patients was 49,31 ± 17,68 years, the sex-ratio was 2,17. Myocardial infarction was the first indication for anticoagulant treatment, with a rate of 21.05%. Anti vitamin K (AVK) was associated with hemorrhage in 63,16% (n=12) of patients versus 36,84% (n=7) of patients treated with low molecular weight heparins (LMWH); 10 patients had major hemorrhage while nine patients had minor hemorrhage. The average duration of Anti vitamin K (AVK) treatment was 16 ± 58 weeks. Hemorrhage in the digestive tract was the most frequent symptom (31,58%) and, in 89,47% of patients, treatment was associated with platelet aggregation. Treatment of hemorrhagic accident was based on definitive cessation of anticoagulant therapy in 73,68% of patients. Four patients (21.05%) died. The inaccessibility to antidotes such as protamine sulphate and PPSD (Prothrombin, Proconvertine, Stuart factor, and anti-haemophilia B factor) constitutes a real obstacle to adequate treatment for complications; a better education of patients receiving these drugs would be the most important preventive measure, because more than 50% of these accidents are preventable.

Language: fr

Keywords

Anticoagulant; hemorrhage; venous thrombosis