Citation

Yohros A, Ford J, Hinojosa MS. Drug Alcohol Depend. 2018; 189: 178-186.

Affiliation

Department of Sociology, University of Central Florida, 4297 Andromeda Loop N., Orlando, FL, 32816-1360, USA. Electronic address: Melanie.Hinojosa@ucf.edu.

Copyright

(Copyright © 2018, Elsevier Publishing)

DOI

10.1016/j.drugalcdep.2018.05.003

PMID

30049530

Abstract

While there is developing research on how genes moderate the effect of stressful life events on substance use, the limited research has yet to focus on specific stressors. As adolescent dating violence victimization has been linked to various substance use behaviors, the current research seeks to further examine the longitudinal outcomes of adolescent dating violence victimization and the role that genes play in moderating these effects. Specifically, using data from the National Longitudinal Study of Adolescent to Adult Health (Add Health), a series of logistic and negative binomial regressions are run to analyze the direct and interactive effects of adolescent dating violence victimization and a polymorphism (5HTTLPR) in the promoter region of the serotonin transporter gene on both alcohol use problems and marijuana use. The results find that 5HTTLPR interacts with adolescent dating violence victimization to increase odds of marijuana use for the sample. However, the interaction between 5HTTLPR and adolescent dating violence has differential effects for males and females, suggesting sex differences regarding the susceptibility properties of 5HTTLPR. Implications of these findings are discussed.

Copyright © 2018 Elsevier B.V. All rights reserved.

Language: en

Keywords

5HTTLPR; Adolescent dating violence; Gene-Environment interactions; Promoter polymorphism; Stressful life events; Substance use outcomes