Citation

Dennis EL, Wilde EA, Newsome MR, Scheibel RS, Troyanskaya M, Velez C, Wade BSC, Drennon AM, York GE, Bigler ED, Abildskov TJ, Taylor BA, Jaramillo CA, Eapen B, Belanger H, Gupta V, Morey R, Haswell C, Levin HS, Hinds SR, Walker WC, Thompson PM, Tate DF. Proc. IEEE Int. Symp. Biomed. Imaging 2018; 2018: 1386-1389.

Affiliation

University of Missouri-St. Louis, St. Louis, MO, USA.

Copyright

(Copyright © 2018, IEEE)

DOI

10.1109/ISBI.2018.8363830

PMID

30034577

PMCID

PMC6049824

Abstract

Traumatic brain injury (TBI) is a significant cause of morbidity in military Veterans and Service Members. While most individuals recover fully from mild injuries within weeks, some continue to experience symptoms including headaches, disrupted sleep, and other cognitive, behavioral or physical symptoms. Diffusion magnetic resonance imaging (dMRI) shows promise in identifying areas of structural disruption and predicting outcomes. Although some studies suggest widespread structural disruption after brain injury, dMRI studies of military brain injury have yielded mixed results so far, perhaps due to the subtlety of mild injury, individual differences in injury location, severity and mechanism, and comorbidity with other disorders such as post-traumatic stress disorder (PTSD), depression, and substance abuse. We present preliminary dMRI results from the ENIGMA (Enhancing Neuroimaging Genetics through Meta-Analysis) military brain injury working group. We found higher fractional anisotropy (FA) in participants with a history of TBI. Understanding the injury and recovery process, along with factors that influence these, will lead to improved diagnosis and treatment.

Language: en

Keywords

ENIGMA; blast; diffusion MRI; military; traumatic brain injury