Citation

Yoshizawa T, Kamijo Y, Fujita Y, Suzuki Y, Hanazawa T, Usui K, Kishino T. Acute Med. Surg. 2018; 5(3): 289-291.

Affiliation

Department of Pharmacy Saitama Medical University Hospital Iruma-gun Saitama Japan.

Copyright

(Copyright © 2018, Japanese Association for Acute Medicine, Publisher John Wiley and Sons)

DOI

10.1002/ams2.339

PMID

29988682

PMCID

PMC6028797

Abstract

CASE: Is fomepizole necessary after massive ingestion of a mixture of methanol and ethanol? We report the case of a 37-year-old man who was transported to our Poison Center 12 h after ingesting 500 mL of fuel alcohol containing 70% methanol and 30% ethanol in a suicide attempt. On admission, he presented only with somnolence and mild metabolic acidosis. We hypothesized that most of the ethanol had been metabolized. OUTCOME: As the estimated serum concentration of methanol was lethal (242.6 mg/dL), fomepizole was given i.v. and hemodialysis was carried out twice, resulting in complete recovery. Later, the serum concentrations of both methanol and ethanol on admission were found to be 224.1 and 0.51 mg/dL, respectively.

CONCLUSION: Therapeutic intervention was delayed by half a day after ingestion of a product containing methanol and ethanol in the present case. If the patient had arrived earlier, he may have only been treated with hemodialysis, but not fomepizole.

Language: en

Keywords

ethanol; fomepizole; headspace gas chromatography/mass spectrometry; hemodialysis; methanol poisoning