Citation

Hosogaya N, Toida K, Ishihara H, Kugiyama K. Respir. Med. Case Rep. 2018; 24: 12-15.

Affiliation

Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan.

Copyright

(Copyright © 2018, Elsevier Publishing)

DOI

10.1016/j.rmcr.2018.03.010

PMID

29977747

PMCID

PMC6010664

Abstract

A 78 year-old man, who received levofloxacin eye drops as a perioperative prophylactic antibacterial agent for cataract surgery, developed pyrexia and dyspnea, followed by respiratory failure. He was diagnosed as drug-induced lung injury due to levofloxacin, and the symptoms improved after the administration of corticosteroids and discontinuation of levofloxacin eye drops. The incidence of levofloxacin-induced lung injury is rare for its frequent prescription. Moreover, eye drops of it has never been reported to cause lung injury. We should be aware of eye drops as a causative dosage forms of drug-induced lung injury.

Language: en

Keywords

BALF, bronchoalveolar lavage fluid; BNP, brain natriuretic peptide; CT, computed tomography; DLST, drug lymphocyte stimulation test; Drug-induced lung injury; EP, eosinophilic pneumonia; Eosinophilic pneumonia; Eye drop; Levofloxacin; MEPM, meropenem; Ophthalmic solution; PMDA, Pharmaceuticals and Medical Devices Agency; TAZ/PIPC, tazobactam/piperacillin