Citation

Genis-Mendoza AD, López-Narváez ML, Tovilla-Zárate CA, Sarmiento E, Chavez A, Martinez-Magaña JJ, González-Castro TB, Hernández-Díaz Y, Juárez-Rojop IE, Ávila-Fernández Á, Nicolini H. Neuropsychobiology 2017; 76(4): 193-198.

Affiliation

Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.

Copyright

(Copyright © 2017, Karger Publishers)

DOI

10.1159/000490071

PMID

29966133

Abstract

BACKGROUND: The aim of this study was to analyze the possible association of polymorphic variants of the DRD2 and ANKK1 genes with suicide attempt in a Mexican population.

METHODS: We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of DRD2 (rs6275 and rs1799978) and 1 polymorphism of ANKK1 (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models.

RESULTS: Individuals who carried the TT genotype of the rs1800497 showed a 3-fold risk of attempting suicide (OR = 3.01; 95% CI 1.56-5.81, p = 0.001) when evaluated through the recessive model. In an analysis stratified by gender, this risk factor remained present among females (OR = 2.81; 95% CI 1.37-5.75) as well as males (OR = 3.3; 95% CI 1.01-10.77).

CONCLUSION: Our results suggest that the rs1800497 variant of the ANKK1 gene could increase the risk of suicide attempt in a Mexican population. However, further studies using larger samples are necessary to obtain more conclusive results.

© 2018 S. Karger AG, Basel.

Language: en

Keywords

ANKK1 gene; DRD2 gene; Dopamine; Gene; Suicide