Citation

Douglass AR, Smyth U. Ment. Health Clin. 2018; 8(3): 155-158.

Affiliation

Clinical Staff Pharmacist, Sumner Regional Hospital, Gallatin, Tennessee.

Copyright

(Copyright © 2018, College of Psychiatric and Neurologic Pharmacists)

DOI

10.9740/mhc.2018.05.155

PMID

29955561

PMCID

PMC6007642

Abstract

Psychosis after traumatic brain injury (TBI) occurs in up to 10% of cases. Although guideline consensus is lacking regarding drugs of choice for this condition, current literature points to the use of atypical antipsychotics. This case describes a 58-year-old male with major neurocognitive disorder due to TBI with behavioral disturbance that was successfully treated with paliperidone palmitate. In addition to the off-label use of paliperidone, this case also explores the use of forced medication as the initial injection was given per guardian consent. After completion of a literature review, this appears to be the first case report describing the use of a long-acting antipsychotic for the treatment of TBI-related psychosis. This case suggests that paliperidone palmitate may be efficacious for psychosis following TBI; however, further study is warranted.

Language: en

Keywords

antipsychotics; forced; long-acting injectables; off-label; paliperidone palmitate; psychosis; traumatic brain injury