Citation

LoBue C, Woon FL, Rossetti HC, Hynan LS, Hart J, Cullum CM. Neuropsychology 2018; 32(4): 401-409.

Affiliation

Department of Psychiatry, University of Texas Southwestern Medical Center.

Copyright

(Copyright © 2018, American Psychological Association)

DOI

10.1037/neu0000431

PMID

29809031

Abstract

OBJECTIVE: To examine whether history of traumatic brain injury (TBI) is associated with more rapid progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD).

METHOD: Data from 2,719 subjects with MCI were obtained from the National Alzheimer's Coordinating Center. TBI was categorized based on presence (TBI+) or absence (TBI-) of reported TBI with loss of consciousness (LOC) without chronic deficit occurring >1 year prior to diagnosis of MCI. Survival analyses were used to determine if a history of TBI predicted progression from MCI to AD up to 8 years. Random regression models were used to examine whether TBI history also predicted rate of decline on the Clinical Dementia Rating scale Sum of Boxes score (CDR-SB) among subjects who progress to AD.

RESULTS: Across 8 years, TBI history was not significantly associated with progression from MCI to a diagnosis of AD in unadjusted (HR = 0.80; 95% CI [0.63, 1.01]; p =.06) and adjusted (p =.15) models. Similarly, a history of TBI was a nonsignificant predictor for rate of decline on CDR-SB among subjects who progressed to AD (b = 0.15, p =.38). MCI was, however, diagnosed a mean of 2.6 years earlier (p <.001) in TBI+ subjects compared with the TBI- group.

CONCLUSIONS: A history of TBI with LOC was not associated with progression from MCI to AD, but was linked to an earlier age of MCI diagnosis. These findings add to a growing literature suggesting that TBI might reduce the threshold for onset of MCI and certain neurodegenerative conditions, but appears unrelated to progression from MCI to AD. (PsycINFO Database Record

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Language: en