Citation

Desai M, Jain A. J. Neurosurg. Sci. 2018; 62(5): 563-573.

Affiliation

Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.

Copyright

(Copyright © 2018, Minerva Medica)

DOI

10.23736/S0390-5616.18.04476-4

PMID

29790724

Abstract

PURPOSE: Traumatic brain injury has a high incidence worldwide and is associated with significant morbidity and mortality. Moreover, TBI has enduring implications in several domains and limits overall quality of life even in the survivors. Neuroprotective strategies are needed to limit morbidity and mortality associated with this disease process. Insight into the failure of these strategies is required to pursue future research successfully.

BACKGROUND: Several different approaches involving pharmacological, surgical and usage of certain devices have been attempted in traumatic brain injury.

METHODS: We will review the epidemiology of TBI, the impact of secondary brain injury with regards to outcomes and different pharmacological, surgical and temperature modulation strategies in this review.

CONCLUSIONS: Traumatic brain injury has wide spread implications and the socio-economic burden related to TBI has been rising. Traumatic Brain Injury is a challenging disease to intervene on due to its heterogeneity. Studies have been limited by several factors outlined in this article. Future work should incorporate a multicenter approach targeting specific disease processes to yield successful results.

Language: en