Citation

Lv Q, Yi Z. Shanghai Arch. Psychiatry 2018; 30(1): 47-51.

Affiliation

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Copyright

(Copyright © 2018, Shanghai Mental Health Center)

DOI

10.11919/j.issn.1002-0829.217090

PMID

29719358

PMCID

PMC5925599

Abstract

In October 2015, the drug-induced liver diseases group of the Chinese Society of Hepatology drafted and published the first Diagnosis and Treatment Guidelines on Drug-induced Liver Injury in China, giving suggestions on the diagnosis and treatment of drug-induced liver injury (DILI). As a psychiatrist, I have found that in clinical practice both typical and new antipsychotic drugs can induce liver injury to varying degrees. Therefore, it is necessary to quickly and accurately determine the cause of liver injury and the type and severity of injury and establish a solution. This article reviewed relevant literature including the common pathogenesis and clinical manifestations of drug-induced liver injury caused by antipsychotic drugs, laboratory tests, diagnostic criteria and classification, and clinical management strategies. This paper also includes a summary and a perspective on liver injury caused by antipsychotic drugs.

Language: zh

Vernacular Abstract

2015 年10 月中华医学会肝病学分会药物性肝病学组起草并推出了中国首部《药物性肝损伤诊治指南》，对药源性肝损伤（DILI）临床诊治提出了建议。作为精神科医生，临床也发现无论是典型还是新型抗精神病药物均会不同程度引起肝脏损伤，因此需要快速准确的判断肝损伤发生的原因，损伤的类型和程度，确立解决方案。本文复习了相关文献，包括抗精神病药物所致药源性肝损伤常见的发病机制和临床表现、实验室检查、诊断标准和分型、临床管理策略，最后对抗精神病药物所致肝损伤进行了总结和展望。.

Language: zh

Keywords

antipsychotic drugs; drug-induced liver injury