Citation

Bolhuis K, Koopman-Verhoeff ME, Blanken LME, Cibrev D, Jaddoe VWV, Verhulst FC, Hillegers MHJ, Kushner SA, Tiemeier H. Acta Psychiatr. Scand. 2018; 138(1): 15-25.

Affiliation

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Copyright

(Copyright © 2018, John Wiley and Sons)

DOI

10.1111/acps.12891

PMID

29675994

Abstract

OBJECTIVE: Adolescent psychotic-like experiences predict the onset of psychosis, but also predict subsequent non-psychotic disorders. Therefore, it is crucial to better understand the aetiology of psychotic-like experiences. This study examined whether (a) child emotional and behavioural problems at 3 and 6 years, or (b) childhood adversities were associated with psychotic-like experiences at age 10 years.

METHOD: This prospective study was embedded in the Generation R Study; 3984 children (mean age 10 years) completed a psychotic-like experiences questionnaire. Mothers reported problems of their child at ages 3, 6 and 10 years. Additionally, mothers were interviewed about their child's adversities.

RESULTS: Psychotic-like experiences were endorsed by ~20% of children and predicted by both emotional and behavioural problems at 3 years (e.g. emotional-reactive problems: OR_adjusted = 1.10, 95% CI: 1.06-1.15, aggressive behaviour: OR_adjusted = 1.03, 95% CI: 1.02-1.05) and 6 years (e.g. anxious/depressed problems: OR_adjusted = 1.11, 95% CI: 1.06-1.15, aggressive behaviour: OR_adjusted = 1.04, 95% CI: 1.04-1.05). Childhood adversities were associated with psychotic-like experiences (>2 adversities: OR_adjusted = 2.24, 95% CI: 1.72-2.92), which remained significant after adjustment for comorbid psychiatric problems.

CONCLUSION: This study demonstrated associations between early adversities, childhood emotional and behavioural problems and pre-adolescent psychotic-like experiences, which will improve the understanding of children at increased risk of severe mental illness.

© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Language: en

Keywords

childhood adversities; development; prospective; psychosis; psychotic symptoms