Citation

Murdock KW, LeRoy AS, Fagundes CP. Stress Health 2018; 34(3): 457-461.

Affiliation

Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.

Copyright

(Copyright © 2018, John Wiley and Sons)

DOI

10.1002/smi.2808

PMID

29602200

Abstract

Inhibition is the ability to stop one's self from responding, or paying attention, to tempting/distracting stimuli or thoughts. Those with poor inhibition are at greater risk of depression and a variety of diseases of older adulthood than those with better inhibition. Inflammation may be a mechanism underlying these links. A total of 840 participants from the Midlife in the United States study completed a neuropsychological measure of inhibition, a self-report measure of depressive symptoms, and a blood draw.

RESULTS indicated that poor inhibition was associated with high interleukin-6 (IL-6). Inhibition was indirectly associated with metabolic syndrome incidence and depressive symptoms through IL-6.

FINDINGS suggest that IL-6 may be a mechanism linking inhibition with metabolic syndrome and depression.

Copyright © 2018 John Wiley & Sons, Ltd.

Language: en

Keywords

depression; inflammation; inhibition; metabolic syndrome