Citation

Vasquez BP, Tomaszczyk JC, Sharma B, Colella B, Green REA. Neurorehabil. Neural Repair 2018; 32(3): 191-199.

Affiliation

University of Toronto, Toronto, Ontario, Canada.

Copyright

(Copyright © 2018, American Society of Neurorehabilitation, Publisher SAGE Publishing)

DOI

10.1177/1545968318760727

PMID

29561244

Abstract

BACKGROUND: Executive control deficits are deleterious and enduring consequences of moderate-severe traumatic brain injury (TBI) that disrupt everyday functioning. Clinically, such impairments can manifest as behavioural inconsistency, measurable experimentally by the degree of variability across trials of a reaction time (RT) task (also known as intraindividual variability [IIV]). Growing research on cognition after TBI points to cognitive deterioration in the chronic stages postinjury.

OBJECTIVE: To examine the longitudinal recovery of RT characteristics (IIV and more detailed ex-Gaussian components, as well as the number of impulsively quick responses) following moderate-severe TBI.

METHODS: Seventy moderate-severe TBI patients were assessed at 2, 5, 12, and 24+ months postinjury on a go/no-go RT task. RT indices (ex-Gaussian parameters mu and sigma [mean and variability of the normal distribution component], and tau [extremely slow responses]; mean, intraindividual coefficient of variation [ICV], and intraindividual standard deviation [ISD]) were analyzed with repeated-measures multivariate analysis of variance.

RESULTS: ICV, ISD, and ex-Gaussian tau significantly decreased (ie, improved) over time in the first year of injury, but worsened from 1 to 2+ years, as did the frequency of extremely fast responses. These quadratic patterns were accentuated by age and shown primarily in tau (extremely slow) and extremely fast (impulsive) responses.

CONCLUSIONS: The pattern of early recovery followed by decline in executive control function is consistent with growing evidence that moderate-severe TBI is a progressive and degenerative disorder. Given the responsiveness to treatment of executive control deficits, elucidating the trajectory and underpinnings of inconsistent behavioral responding may reveal novel prognostic and clinical management opportunities.

Language: en

Keywords

attention; ex-Gaussian; executive control; neurodegeneration; postacute decline; recovery; traumatic brain injury; variability