Citation

Saavedra SL, Avila L, Giudicessi SL, Albericio F, Camperi SA, Cascone O, Martinez-Ceron MC. Curr. Pharm. Des. 2018; 24(16): 1737-1747.

Affiliation

Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Catedra de Biotecnologia, Junin 956, 1113, Buenos Aires. Argentina.

Copyright

(Copyright © 2018, Bentham Science Publishers)

DOI

10.2174/1381612824666180223172854

PMID

29546833

Abstract

Nowadays, treatment with specific antivenins is considered the only cure for snakebites accidents. However, access to antivenom obstructs the successful implementation of the World Health Organization international guidelines. In the last few years, natural organic compounds, peptides and proteins with the ability to inhibit snake toxins and obtained from different sources such as plant extracts and animal blood have been proposed as antivenoms. In this work, we will focus on the inhibitors of the main venom toxins, phospholipases A2 and metalloproteinases, and their application as novel antivenoms.

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Language: en

Keywords

Antivenom; inhibition; metalloproteinases; peptides; phospholipase A2.; plant extracts; protein