Citation

Holt NR, Nickson CP. Intern. Med. J. 2018; 48(3): 335-339.

Affiliation

Intensive Care Unit, Alfred Hospital, Melbourne, Victoria, Australia.

Copyright

(Copyright © 2018, John Wiley and Sons)

DOI

10.1111/imj.13725

PMID

29512320

Abstract

A 22-year-old woman presented with methanol toxicity manifesting as headache, reduced conscious state and visual change after consuming home-made grappa. She progressed to a coma with fixed mydriasis and severe acidaemia (pH 6.55). She was treated with empirical antidote administration (intravenous ethanol) and enhanced elimination through haemodialysis. She survived despite her delayed presentation but developed significant neurological sequelae, including visual impairment. We provide an overview of key elements of diagnosis and recent updates in treatment recommendations.

© 2018 Royal Australasian College of Physicians.

Language: en

Keywords

metabolic disorder; methanol poisoning; neurotoxicity; renal replacement therapy; toxicology