Citation

Huber-Lang M, Lambris JD, Ward PA. Nat. Immunol. 2018; 19(4): 327-341.

Affiliation

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

Copyright

(Copyright © 2018, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1038/s41590-018-0064-8

PMID

29507356

Abstract

Trauma can affect any individual at any location and at any time over a lifespan. The disruption of macrobarriers and microbarriers induces instant activation of innate immunity. The subsequent complex response, designed to limit further damage and induce healing, also represents a major driver of complications and fatal outcome after injury. This Review aims to provide basic concepts about the posttraumatic response and is focused on the interactive events of innate immunity at frequent sites of injury: the endothelium at large, and sites within the lungs, inside and outside the brain and at the gut barrier.

Language: en