Citation

Eric Nyam TT, Ho CH, Wang YL, Lim SW, Wang JJ, Chio CC, Kuo JR, Wang CC. World Neurosurg. 2018; 113: e328-e335.

Affiliation

Departments of Neurosurgery, Chi-Mei Medical Center, Tainan, Taiwan; Center for General Education, Southern Taiwan University of Science and Technology, Tainan, Taiwan. Electronic address: kuojinnrung@gmail.com.

Copyright

(Copyright © 2018, Elsevier Publishing)

DOI

10.1016/j.wneu.2018.02.027

PMID

29452320

Abstract

BACKGROUND: Previous studies have implicated traumatic brain injury (TBI) as a risk factor for Parkinson's disease (PD). However, the incidence risk of new-onset TBI among patients with PD is not well established. This study investigated the contribution of PD to new-onset TBI associations. MATERIAL AND METHODS: The study selected 6,076 patients with PD and using 1:2 propensity score matching 12,152 general population cohorts in a longitudinal population database in Taiwan.The Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of TBI adjusted with the potential confounding factors.

RESULTS: The incidence of TBI in patients with PD (2.57%) and compared cohorts (1.81%) was significantly different (p=.0007). Patients with PD had a higher risk ofTBI (HR =1.63; 95% confidence interval [CI], 1.32-2.01) compared to the general population.Patients with PD with TBI incidence had a higher Charlson'scomorbidity index score than the general population with TBI outcome (p<.0001). Fall is the major cause of TBI in patients with PD.

CONCLUSIONS: This study demonstrated that patients with PDhave a highrisk of TBI, andthe major cause of TBI in patients with PD is fall.

Copyright © 2018 Elsevier Inc. All rights reserved.

Language: en

Keywords

National Health Insurance Research Database; Parkinson’s disease; propensity score; traumatic brain injury