Citation

Asorey LG, Carbone S, Gonzalez BJ, Cutrera RA. Neurosci. Lett. 2018; 670: 1-7.

Affiliation

Universidad de Buenos Aires, CONICET, Instituto de Fisiología y Biofísica "Bernardo Houssay" (IFIBIO), Buenos Aires, Argentina. Electronic address: racutrera@gmail.com.

Copyright

(Copyright © 2018, Elsevier Publishing)

DOI

10.1016/j.neulet.2018.01.030

PMID

29355695

Abstract

In last few years it has been a significant increase in the consumption of alcohol combined with energy drink. The aim of this work was to study the effect of this mixture in motor and affective behaviors during an alcohol hangover episode. Male Swiss mice received one of the following treatments: saline + sucrose; saline + energy drink; ethanol + sucrose; ethanol + energy drink. Ethanol dose was 3.8 g/kg BW (i.p.) and energy drink dose was 18 ml/kg BW (gavage) at ZT1 (8 am) (ZT: Zeitgeber time; ZT0: 7 am; lights on). The behavioral tests used were tight rope test to determine motor coordination; hanging wire test to study muscular strength; elevated plus maze and open field tests to evaluate anxiety like-behavior and locomotor activity. Tests were carried out at basal point that matched with lights onset and every 6 hours up to 18 hours after treatments. Hangover onset was established at ZT7 when blood alcohol concentration (BAC) was almost zero. Our results showed that the mixture of alcohol and energy drink altered significantly motor skills. Specifically, a significant decrease was observed in the performance of the animals in the tightrope and hanging wire tests in groups treated with the mixture of alcohol and energy drink. A significant impairment in the anxiety-like behavior was observed mainly at the beginning of alcohol hangover. These findings suggest that energy drink added to alcohol extends motor disabilities observed during an alcohol hangover episode in comparison with animals that received alcohol alone.

Copyright © 2018. Published by Elsevier B.V.

Language: en

Keywords

alcohol; alcohol hangover; anxiety-like behavior; energy drinks; locomotor activity; mice; neuromuscular coordination