Citation

Pohanka M. Ceska Slov. Farm. 2017; 66(4): 147-153.

Vernacular Title

Stanovení aktivity cholinesteras a jejich využití pro diagnostiku patologických stavů.

Copyright

(Copyright © 2017, Ceska Lekarska Spolecnost J. E. Purkyne)

DOI

unavailable

PMID

29351376

Abstract

Cholinesterases are enzymes important for some nerve transmissions where the enzyme acetylcholinesterase plays a crucial role. The second enzyme, butyrylcholinesterase, is not necessary for the neurotransmission but it is involved in some detoxification reactions. A survey of literature, a discussion of diagnostic importance and the methods for an activity assay are presented in this review article. Liver failures, exposure to neurotoxic compounds, genetic dispositions are outlined here. In the field of assays, spectrophotometric, colorimetric and electrochemical tests are discussed.

Key words: acetylcholinesterase butyrylcholinesterase poisoning liver function test pesticide nerve agent Alzheimer disease pathological state.

Language: cs