Citation

Wildes TM, Fiala MA. Eur. J. Haematol. 2018; 100(3): 273-278.

Affiliation

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis MO.

Copyright

(Copyright © 2018, John Wiley and Sons)

DOI

10.1111/ejh.13009

PMID

29239009

Abstract

OBJECTIVE: To examine the prevalence of falls, factors associated with falls and the relationship between falls and survival in older adults with multiple myeloma METHODS: In an analysis of the Surveillance, Epidemiology and End Results (SEER)-Medicare Health Outcomes Survey (MHOS) linked database, we examined 405 older adults with MM and 513 matched non-cancer controls. The primary outcome was self-reported within the past 12 months. Age, race, gender, symptoms and comorbidities were self-reported in the MHOS. Survival was calculated from SEER data RESULTS: Of the patients with MM, 171 were within 1 year of diagnosis (cohort 1) and 234 were ≥1 year post-diagnosis (cohort 2). Patients in cohort 1 and 2 were more likely to have fallen than controls (26% and 33% vs 23%, p=0.012). On multivariate analysis, among patients with myeloma (combined cohorts 1&2), factors associated with falls included self-report of fatigue [aOR 2.52 (95% CI 1.34-4.93)], depression [aOR 1.90 (95% CI 1.14-3.18)], or poorer general health [aOR 1.86 (95% CI 1.05-3.36)]. Falls were not associated with survival CONCLUSIONS: Older adults with MM have a greater prevalence of falls than matched controls. Self- reported fatigue, depression and poorer general health are associated with greater odds of falls. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

Language: en

Keywords

Cancer; Elderly; Falls; Geriatric Assessment; Multiple Myeloma