Citation

Anderson A, McConville A, Fanthorpe L, Davis J. Medicines (Basel) 2017; 4(3): e4030048.

Affiliation

School of Engineering, Ulster University, Jordanstown, Northern Ireland BT37 0QB, UK. james.davis@ulster.ac.uk.

Copyright

(Copyright © 2017, MDPI: Multidisciplinary Digital Publishing Institute)

DOI

10.3390/medicines4030048

PMID

28930263

Abstract

The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over the past decade and continues to pose a risk to children and adults alike. The aim of the review has been to cast a spotlight on the drug and assess why its use remains problematic, how technology could offer more efficacious delivery regimes, and minimise the possibility of accidental or intentional misuse.

Language: en

Keywords

methyl salicylate; microneedle; smart patches; toxicity; transdermal