Citation

Dai JX, Ma YB, Le NY, Cao J, Wang Y. Int. J. Neurosci. 2018; 128(3): 243-254.

Affiliation

b Department of Emergency , Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200082 , China.

Copyright

(Copyright © 2018, Informa - Taylor and Francis Group)

DOI

10.1080/00207454.2017.1380008

PMID

28918695

Abstract

Traumatic brain injury (TBI) is a devastating and common health problem in today's society. Relevant animal models of TBI provide powerful tools to study TBI in a controlled, rigorous and cost-efficient manner. The mostly used animals in TBI studies so far are rodents, however, huge inter-species differences in anatomy, morphology, metabolism, neurobiology, and lifespan between rodents and humans have impeded the translation of research findings from labs to human. Compared with rodents, large animals (eg. swine, rabbit, sheep, ferret) show great advantages in modelling TBI due to the similarity of their brains to human brain. Actually, large animal models of TBI play crucial role in determining the underlying mechanisms and screening putative therapeutic targets of TBI. Previously, relevant reviews about large animal TBI models are extremely rare; in this review, we majorly summarize current common large animal models of TBI, including discussion on the available research methodologies in previous studies, several potential therapies in large animal trials of TBI, as well as advantages and disadvantages of these models.

Language: en

Keywords

Large animal models; Review; Traumatic brain injury