Citation

Arantes LC, Júnior EF, de Souza LF, Cardoso AC, Alcântara TLF, Lião LM, Machado Y, Lordeiro RA, Neto JC, Andrade AFB. Forensic Toxicol. 2017; 35(2): 408-414.

Affiliation

School of Chemistry, University of Lincoln, Brayford Pool, Lincoln, LN6 7TS UK.

Copyright

(Copyright © 2017, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s11419-017-0357-x

PMID

28706567

PMCID

PMC5486617

Abstract

A new potent serotonin 5-HT2A receptor agonist was identified in blotter papers by several state level forensic laboratories in Brazil. The 25I-NBOH is a labile molecule, which fragments into 2C-I when analyzed by routine seized material screening gas chromatography (GC) methods. GC-mass spectrometry (MS), liquid chromatography-quadrupole time-of-flight-MS, and Fourier transform infrared and nuclear magnetic resonance analyses were performed to complete molecular characterization. Individual doses range from 300 to 1000 μg. Despite its being a potent 5-HT2A receptor agonist, 25I-NBOH is neither registered in the United Nations Office on Drugs and Crime (UNODC) nor classified as a scheduled substance in most countries. Sweden and Brazil seem to be the only countries to control 25I-NBOH. To our knowledge, this is the first scientific report dealing with identification of 25I-NBOH in actual seizures.

Language: en

Keywords

25I-NBOH; 5-HT2A receptor agonist; NBOH; NPS; Phenethylamine derivatives