Citation

Li J, Tang L, Wang Y, Li F, Bao M, Xiang J, Lei D, Tang B. Genet. Test. Mol. Biomarkers 2017; 21(8): 497-505.

Affiliation

Department of Neurology, Xiangya Hospital, Central South University , Changsha, Hunan, China .

Copyright

(Copyright © 2017, Mary Ann Liebert Publishers)

DOI

10.1089/gtmb.2016.0417

PMID

28686058

Abstract

AIMS: The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) play important roles in hypothalamic-pituitary-adrenal axis and stress regulation. The current study aimed to address the genetic association and gene-gene interactions between GR and MR gene polymorphisms and aggressive behavior.

METHODS: A haplotype-based, case-control study was designed to examine the association between human MR and GR genes and aggressive behaviors, including robbery and intentional interpersonal injury, in a central south Chinese Han population. Eight well-studied polymorphisms of the MR gene (rs2070951, rs2871, rs5522, and rs5525) and the GR gene (rs10482605, rs6190, rs1800445, and rs6196) were genotyped using SNaPshot.

RESULTS: The MR and GR gene polymorphisms were not associated with aggressive behaviors, including in robbery and intentional interpersonal injury subgroups (p > 0.05). The frequency of haplotype TAAT of GR was significantly higher in the control group than that in the case group (p = 0.004, padj = 0.02). In addition, a two-way interaction between GR rs1800445 and MR rs2070951 and aggressive behavior was also found (p = 0.01).

CONCLUSIONS: The haplotype TAAT of GR might be a protective factor against aggressive behavior, while gene-gene interactions between GR rs1800445 and MR rs2070951 might be a risk factor for aggressive behavior in the Central South Chinese Han population.

Language: en

Keywords

gene–gene interaction; glucocorticoid receptor (GR); mineralocorticoid receptor (MR); polymorphism