Citation

Steenerson K, Starling AJ. Neurol. Clin. 2017; 35(3): 403-408.

Affiliation

Neurology, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, Arizona 85054, USA. Electronic address: starling.amaal@mayo.edu.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.ncl.2017.03.011

PMID

28673406

Abstract

Concussion pathophysiology is complicated and involves numerous mechanisms, including excessive neurotransmitter release, metabolic derangements, neuroinflammation, cerebral blood flow changes, and axonal disruption. The initial biomechanical impact in a concussion results in abnormal function at the cellular level, which initiates a cascade of events that leads to microstructural changes and, in the minority of cases, more persistent, permanent damage.

Copyright © 2017 Elsevier Inc. All rights reserved.

Language: en

Keywords

Concussion; TBI; Trauma; Traumatic brain injury