Citation

Wang X, Ren X, Wang Y, Li J, Guo T, Li F, Zhao Z. Pak. J. Pharm. Sci. 2017; 30(3): 997-1000.

Affiliation

Department of Neurosurgery, Heji Hospital, Changzhi Medical College, ChangZhi City, Shanxi Province, China.

Copyright

(Copyright © 2017, Faculty of Pharmacy, University of Karachi)

DOI

unavailable

PMID

28655698

Abstract

The objective of this paper is to study the expression of caveolin-1 in the traumatic brain injury patients and its relationship with disease prognosis. Caveolin-1 was measured in 52 patients with ventricular hemorrhage within 8h, 24h, 48h, 72h and 1 week after onset by enzyme-linked immunosorbent assay (ELISA), to observe the changes of cerebrospinal fluid caveolin-1. The level of caveolin-1 in the brain of all patients was higher than that of the control group at 8 h, 24h, 48 h, 72h and 1 weeks after the onset (P<0.05) and the level of caveolin-1 in cerebrospinal fluid (CSF) of the severe group was higher than that of the light-medium group within 8h, 24h, 48 h and 72h after the onset (P<0.05). The level of caveolin-1 in CSF was significantly increased in patients with ventricular hemorrhage within 8h, 24h, 48h, 72h and 1 weeks after onset, and the expression of caveolin-1 in brain was related to the severity of craniocerebral injury. Therefore, the expression of caveolin-1 can be used as an indicator of the prognosis of traumatic brain injury disease.

Language: en