Citation

Yu X, Correll CU, Xiang YT, Xu Y, Huang J, Yang F, Wang G, Si T, Kane JM, Masand P. Shanghai Arch. Psychiatry 2016; 28(5): 241-252.

Affiliation

Duke-NUS Medical School, Academic Medicine Education Institute, Singapore.

Copyright

(Copyright © 2016, Shanghai Mental Health Center)

DOI

10.11919/j.issn.1002-0829.216072

PMID

28638198

PMCID

PMC5434280

Abstract

Acute agitation and aggression are common symptoms in patients with bipolar disorder and schizophrenia. In this review, we discuss the prevalence, clinical assessment strategies, treatment options, and current Western and Chinese guidelines for the management of acute agitation and aggression in patients with bipolar disorder or schizophrenia. Among available approaches, we discuss in detail recent evidence supporting the use of intramuscular (IM) antipsychotics and some recently approved oral atypical antipsychotics for the management of acute aggression and agitation in hospitalized patients with bipolar disorder or schizophrenia presenting with acute agitation or aggression, highlighting some differences between individual antipsychotic agents.


KEYWORDS:
Aggression; Agitation; Antipsychotic; Bipolar disorder; Schizophrenia

Language: en

Vernacular Abstract

急性激越和敌对是双相障碍和精神分裂症患者的常见症状。本综述中，我们讨论在双相障碍或精神分裂症患者中上述症状的发生率、临床评估策略、治疗方案以及目前国内外针对这些症状的治疗指南。在现有的方法中，有使用肌肉注射的抗精神病药物和最近获得批准的口服非典型抗精神病药物治疗双相障碍或精神分裂症住院患者的急性激越和敌对，我们详细讨论了支持这些方法的最新证据，并强调各个抗精神病药物之间的一些差异。.

Language: en

Keywords

Aggression; Agitation; Antipsychotic; Bipolar disorder; Schizophrenia