Citation

Manchia M, Fanos V. Prog. Neuropsychopharmacol. Biol. Psychiatry 2017; 77: 32-41.

Affiliation

Department of Surgical Sciences, University of Cagliari and Neonatal Intensive Care Unit, Cagliari, Italy; Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, Cagliari, Italy. Electronic address: vafanos@tin.it.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.pnpbp.2017.03.024

PMID

28372995

Abstract

Human aggression is a complex and widespread social behavior that is overrepresented in individuals affected by severe mental illness (SMI), such as schizophrenia (SCZ), bipolar disorder (BD), autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD). A substantial proportion of the liability threshold for aggressive behavior is determined by genetic factors, and environmental moderators might facilitate the manifestation of this behavioral phenotype through modification of gene expression via the epigenetic machinery. These specific alterations in the genetic and epigenetic make-up of aggressive individuals might determine specific biochemical modifications detectable through metabolomics. An additional pathophysiological component playing a role in aggressive behavior might be determined by alterations of gut microbiota. Here, we present a selective review of the human data on genetic, epigenetic, and metabolomic markers of aggressive behavior in SMI, discussing also the available evidence on the role of microbiome alterations. Clinical implication of these evidences, as well as future perspectives, will be discussed.

Copyright © 2017. Published by Elsevier Inc.

Language: en

Keywords

Attention-deficit/hyperactivity disorder; Autism; Bipolar disorder; Epigenetics; Gene-environment interaction; Metabolome; Microbiome; Schizophrenia