SAFETYLIT WEEKLY UPDATE

We compile citations and summaries of about 400 new articles every week.
RSS Feed

HELP: Tutorials | FAQ
CONTACT US: Contact info

Search Results

Journal Article

Citation

Qi S, Mu YF, Cui LB, Zhang J, Guo F, Tan QR, Shi M, Liu K, Xi YB, Zhang NY, Zhang XL, He Y, Yang J, Yin H. Brain Imaging Behav. 2018; 12(2): 390-401.

Affiliation

Department of Radiology, Xijing Hospital, Fourth Military Medical University, No.127 West Changle Road, Xi'an, Shaanxi Province, 710032, China. yinhong@fmmu.edu.cn.

Copyright

(Copyright © 2018, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s11682-017-9693-z

PMID

28293804

Abstract

Alterations of the topological organization of abnormal regions or network-level structural aberrations are still poorly understood for post-traumatic stress disorder (PTSD). Herein, we investigated brain structural networks in recent-onset PTSD patients, all affected by the coalmine-flood disaster. Cortical networks were studied in recent onset PTSD patients (n = 15) and matched healthy controls (n = 25). Cortical networks were constructed by thresholding correlation matrices of 150 regions and quantified using graph theoretical approaches. Contributions of high-degree nodes, and regional and global network measures, including degree and betweenness, were studied. Compared with healthy controls, PTSD patients showed altered quantitative values in global network properties, characterized by shorter path length and higher clustering. Moreover, PTSD patients exhibited decreased connectivity in the right lingual gyrus, parahippocampal gyrus, left supramarginal gyrus, parahippocampal gyrus, bilateral superior and inferior frontal gyrus, superior frontal gyrus, and posterior cingulate gyrus. Nodal centrality decreased predominantly in the occipital regions (lingual gyrus) and default-mode regions, while increased correlations and centralities were observed in the medial temporal lobe and posterior cingulate cortex. PTSD-related networks exhibited a less efficient organization and regional connectivity. According to these findings, we conclude that regional connections involving fear-processing and re-experiential-processing cortex may play a role in maintaining or adapting to PTSD pathology.


Language: en

Keywords

Cortex thickness; Gray matter; Post-traumatic stress disorder; Small world networks; Structural networks

NEW SEARCH


All SafetyLit records are available for automatic download to Zotero & Mendeley
Print