Citation

Rudolph MD, Miranda-Domínguez O, Cohen AO, Breiner K, Steinberg L, Bonnie RJ, Scott ES, Taylor-Thompson K, Chein J, Fettich KC, Richeson JA, Dellarco DV, Galvan A, Casey BJ, Fair DA. Dev. Cogn. Neurosci. 2017; 24: 93-106.

Affiliation

Department of Behavioral Neuroscience, Department of Psychiatry, Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States. Electronic address: faird@ohsu.edu.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.dcn.2017.01.010

PMID

28279917

Abstract

Developmental differences regarding decision making are often reported in the absence of emotional stimuli and without context, failing to explain why some individuals are more likely to have a greater inclination toward risk. The current study (N=212; 10-25y) examined the influence of emotional context on underlying functional brain connectivity over development and its impact on risk preference. Using functional imaging data in a neutral brain-state we first identify the "brain age" of a given individual then validate it with an independent measure of cortical thickness. We then show, on average, that "brain age" across the group during the teen years has the propensity to look younger in emotional contexts. Further, we show this phenotype (i.e. a younger brain age in emotional contexts) relates to a group mean difference in risk perception - a pattern exemplified greatest in young-adults (ages 18-21). The results are suggestive of a specified functional brain phenotype that relates to being at "risk to be risky."

Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Language: en

Keywords

Brain age; Emotional state; Multivariate; Prediction; Pseudo-resting state fMRI; Risky behavior