Citation

Oren N, Ash EL, Tarrasch R, Hendler T, Giladi N, Shapira-Lichter I. Neurobiol. Aging 2017; 53: 93-102.

Affiliation

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.neurobiolaging.2017.01.020

PMID

28242539

Abstract

Working memory (WM) declines with age. Older adults, however, perform similar to younger adults in WM tasks with negative distractors at low WM load. To clarify the neural basis of this phenomenon, older (n = 28) and younger (n = 24) adults performed an emotional n-back task during an fMRI scan, and activity in task-related regions was examined. Comparing negative with neutral distraction at low WM load, older adults demonstrated shorter reaction times (RT) and reduced activation in frontoparietal regions: bilateral middle frontal gyrus (MFG) and left parietal cortex. They also had greater coherence within the frontoparietal network, as well as greater deactivation of the ventromedial prefrontal cortex and the amygdala. These patterns probably contributed to the older adults' diminished distractibility by negative task-irrelevant stimuli. Since recruitment of control mechanisms was less required, the frontoparietal network was less activated and performance was improved. Faster RT during the negative condition was related to lesser activation of the MFG in both age groups, corroborating the functional significance of this region to WM across the lifespan.

Copyright © 2017 Elsevier Inc. All rights reserved.

Language: en

Keywords

Aging; Distractibility; Emotion