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Citation
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Brondino N, Rocchetti M, Fusar-Poli L, Codrons E, Correale L, Vandoni M, Barbui C, Politi P. Acta Psychiatr. Scand. 2017; 135(4): 285-295. |
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Abstract
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OBJECTIVE: The aim of the present systematic review and meta-analysis was to evaluate the impact of physical exercise on cognitive symptoms in depressed adult patients.
METHODS: Systematic literature search was performed in Web of Science™ and CINAHL from inception to August 2016. Two reviewers independently selected randomized trials evaluating the effect of exercise on cognitive functions in patients with a validated diagnosis of depression. Outcome measures included global cognition and different cognitive domains (speed of processing, attention/vigilance, working memory, verbal and visual memory, and reasoning).
RESULTS: Eight trials met inclusion criteria (637 patients). A fixed-effects model showed absence of beneficial effect on global cognition (Hedges' g = 0.07, 95% CI -0.08 to 0.24, I(2 ) = 0%) as well as on specific cognitive domains. Sensitivity analyses did not show an impact of exercise in studies with shorter intervention duration compared to longer trials (between group heterogeneity Q = 3.564, df = 1, P = 0.059), single session per week compared to multiple sessions (Q = 2.691, df = 1, P = 0.101) and low exercise intensity compared with moderate/high intensity (Q = 2.952, df = 1, P = 0.086).
CONCLUSION: Our meta-analysis did not observe a substantial benefit of physical exercise on cognitive symptoms in depression.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Language: en |