Citation

Feliu C, Guillemin H, Gozalo C, Fouley A, Marty H, Millart H, Djerada Z. Ann. Biol. Clin. (JLE) 2017; 75(1): 83-86.

Vernacular Title

Faux négatif lors d’une intoxication avérée chez deux enfants par le lorazépam.

Affiliation

Laboratoire de pharmacologie et toxicologie, Hôpital Maison Blanche, CHU de Reims, Reims, France, SFR Cap-Santé-EA3801-Université de Reims, Laboratoire de pharmacologie médicale, Faculté de médecine de Reims, Reims, France.

Copyright

(Copyright © 2017, John Libbey Eurotext)

DOI

10.1684/abc.2016.1209

PMID

28067201

Abstract

Children aged between 1 to 4 years are the most at risk of unintentional poisonings. Benzodiazepines are the most medicine often cause of the poisoning. Among the twenty-two most prescribed benzodiazepines in France, lorazepam ranks fifth behind zolpidem, alprazolam, bromazepam and zopiclone. However the automated assay currently available does not allow to detect and/or to quantify lorazepam. The alternative to the immunoassay is the liquid chromatography coupled with mass spectrometry (HPLC/MS). This technique, highly sensitive and specific, requires a pre-treatment phase and a good technical proficiency, justifying specialized staff. The clinical cases presented here illustrate the major interest of availability to this type of technology in routine and 24h/24h.

Language: en