Citation

Hajra A, Bandyopadhyay D. Indian J. Endocrinol. Metab. 2016; 20(5): 737-738.

Affiliation

Department of Accident and Emergency, Lady Hardinge Medical College, New Delhi, India.

Copyright

(Copyright © 2016, Medknow Publications)

DOI

10.4103/2230-8210.190592

PMID

27730094

Abstract

Several postulations are there to explain the interrelationship of Vitamin D and muscle strength. The Vitamin D receptors are found to be expressed in human muscle tissue. ] Studies among older individuals suggested that Vitamin D receptor activation in muscle induces de novo protein synthesis. This effect is particularly seen in type II fast twitch muscle fibers. This finding proposed an association between muscle strengthening the effect of Vitamin D and prevention of fall.

Several studies have found the beneficiary impact of this vitamin on muscle strength. However, reversed results are also there. A meta-analyses of double-blind, randomized control trial (RCT) support a benefit of Vitamin D supplementation in the prevention of falls and hip fractures among patients of 65 years and older at high risk of Vitamin D deficiency. However, questionable outcomes are also there in meta-analyses where this age restriction is not maintained.

Currently, we have come to know about another study (NCT01017354). It is a 1-year, double-blind, randomized clinical trial conducted in Zurich, Switzerland. Analysis of data was done from June 15, 2012, to October 10, 2015. The study was done involving 200 community-dwelling men and women 70 years and older with a prior fall...

Language: en