Citation

Desmyter S, Duprat R, Baeken C, Van Autreve S, Audenaert K, van Heeringen CK. Front. Hum. Neurosci. 2016; 10: e480.

Affiliation

Unit for Suicide Research, Department of Psychiatry and Medical Psychology, Ghent University Ghent, Belgium.

Copyright

(Copyright © 2016, Frontiers Research Foundation)

DOI

10.3389/fnhum.2016.00480

PMID

27729854

Abstract

OBJECTIVES: We aimed to examine the effects and safety of accelerated intermittent Theta Burst Stimulation (iTBS) on suicide risk in a group of treatment-resistant unipolar depressed patients, using an extensive suicide assessment scale.

METHODS: In 50 therapy-resistant, antidepressant-free depressed patients, an intensive protocol of accelerated iTBS was applied over the left dorsolateral prefrontal cortex (DLPFC) in a randomized, sham-controlled crossover design. Patients received 20 iTBS sessions over 4 days. Suicide risk was assessed using the Beck Scale of Suicide ideation (BSI).

RESULTS: The iTBS protocol was safe and well tolerated. We observed a significant decrease of the BSI score over time, unrelated to active or sham stimulation and unrelated to depression-response. No worsening of suicidal ideation was observed. The effects of accelerated iTBS on mood and depression severity are reported in Duprat et al. (2016). The decrease in suicide risk lasted up to 1 month after baseline, even in depression non-responders.

CONCLUSIONS: This accelerated iTBS protocol was safe. The observed significant decrease in suicide risk was unrelated to active or sham stimulation and unrelated to depression response. Further sham-controlled research in suicidal depressed patients is necessary. (Clinicaltrials.gov identifier: NCT01832805).

Language: en