Citation

Shi J, Dong B, Mao Y, Guan W, Cao J, Zhu R, Wang S. Oncotarget 2016; 7(43): 71052-71061.

Affiliation

Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Copyright

(Copyright © 2016, Impact Journals)

DOI

10.18632/oncotarget.11958

PMID

27626493

Abstract

Hyperglycemia after severe traumatic brain injury (TBI) occurs frequently and is associated with poor clinical outcome and increased mortality. In this review, we highlight the mechanisms that lead to hyperglycemia and discuss how they may contribute to poor outcomes in patients with severe TBI. Moreover, we systematically review the proper management of hyperglycemia after TBI, covering topics such as nutritional support, glucose control, moderated hypothermia, naloxone, and mannitol treatment. However, to date, an optimal and safe glycemic target range has not been determined, and may not be safe to implement among TBI patients. Therefore, there is a mandate to explore a reasonable glycemic target range that can facilitate recovery after severe TBI.

Language: en