Citation

An D, Chen W, Yu DQ, Wang SW, Yu WZ, Xu H, Wang DM, Zhao D, Sun YP, Wu JC, Tang YY, Yin SM. Anim. Sci. J. 2016; 88(5): 798-806.

Affiliation

College of Basic Medical Sciences, Dalian Medical University, Dalian, China. dlshengming@163.com.

Copyright

(Copyright © 2016, Japanese Society of Zootechnical Science, Publisher John Wiley and Sons)

DOI

10.1111/asj.12688

PMID

27619417

Abstract

Both Kunming (KM) mice and BALB/c mice have been widely used as rodent models to investigate stress-associated mental diseases. However, little is known about the different behaviors of KM mice and BALB/c mice after social isolation, particularly cognitive and aggressive behaviors. In this study, the behaviors of KM and BALB/c mice isolated for 2, 4 and 8 weeks and age-matched controls were evaluated using object recognition, object location and resident-intruder tests. The recovery of behavioral deficits by re-socialization was also examined for the isolated mice in adolescence. Our study showed that isolation for 2, 4 and 8 weeks led to cognitive deficits and increased aggressiveness for both KM and BALB/c mice. An important finding is that re-socialization could completely recover spatial/non-spatial cognitive deficits resulted from social isolation for both KM and BALB/c mice. In addition, age only impacted aggressiveness of KM mice. Moreover, isolation duration showed different impacts on cognitive and aggressive behaviors for both KM and BALB/c mice. Furthermore, BALB/c mice showed weak spatial/non-spatial memory and low aggressiveness when they were at the same age and isolation duration, compared to KM mice. In conclusion, KM mice and BALB/c mice behaved characteristically under physiology and isolation conditions.

© 2016 Japanese Society of Animal Science.

Language: en