Citation

Pareja JC, Keeley K, Duhaime AC, Dodge CP. Methods Mol. Biol. 2016; 1462: 345-356.

Affiliation

Dartmouth Hitchcock Medical Center, Lebanon, NH, 03766, USA.

Copyright

(Copyright © 2016, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/978-1-4939-3816-2_19

PMID

27604727

Abstract

The brain has different responses to traumatic injury as a function of its developmental stage. As a model of injury to the immature brain, the piglet shares numerous similarities in regards to morphology and neurodevelopmental sequence compared to humans. This chapter describes a piglet scaled focal contusion model of traumatic brain injury that accounts for the changes in mass and morphology of the brain as it matures, facilitating the study of age-dependent differences in response to a comparable mechanical trauma.

Language: en