Citation

Cissé YM, Peng J, Nelson RJ. Chronobiol. Int. 2016; 33(10): 1473-1480.

Affiliation

a Department of Neuroscience, Neuroscience Research Institute, Behavioral Neuroendocrinology Group , The Ohio State University Wexner Medical Center , Columbus , OH , USA.

Copyright

(Copyright © 2016, Informa - Taylor and Francis Group)

DOI

10.1080/07420528.2016.1221418

PMID

27592634

Abstract

Dim light at night (dLAN) disrupts circadian organization and influences adult behavior. We examined early dLAN exposure on adult affective responses. Beginning 3 (juvenile) or 5 weeks (adolescent) of age, mice were maintained in standard light-dark cycles or exposed to nightly dLAN (5 lx) for 5 weeks, then anxiety-like and fear responses were assessed. Hypothalami were collected around the clock to assess core clock genes. Exposure to dLAN at either age increased anxiety-like responses in adults. Clock and Rev-ERB expression were altered by exposure to dLAN. In contrast to adults, dLAN exposure during early life increases anxiety and fear behavior.

Language: en