Citation

Neider D, Lindström LH, Bodén R. Neuropsychiatr. Dis. Treat. 2016; 12: 1711-1714.

Affiliation

Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden.

Copyright

(Copyright © 2016, Dove Press)

DOI

10.2147/NDT.S107178

PMID

27468235

Abstract

BACKGROUND: The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF), bullying, and later suicide among patients with schizophrenia.

METHODS: Ninety-nine patients with schizophrenia were included. Correlations of clinical factors, 5-HIAA and HVA, and later suicide were investigated.

RESULTS: Twelve patients committed suicide (12%) during a 28-year follow-up period. Later suicide was correlated to bullying in childhood (P=0.02) and a lower quotient of HVA/5-HIAA in CSF (P<0.05).

CONCLUSION: Suicide in schizophrenia is related to childhood exposedness and CSF neurotransmitter levels.

Language: en