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Citation |
Chisholm RH, Trauer JM, Curnoe D, Tanaka MM. Proc. Natl. Acad. Sci. U. S. A. 2016; 113(32): 9051-9056. |
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Affiliation |
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 2052, Australia; Evolution & Ecology Research Centre, University of New South Wales, Sydney 2052, Australia; m.tanaka@unsw.edu.au. |
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Copyright |
(Copyright © 2016, National Academy of Sciences) |
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DOI |
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PMID |
27457933 |
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Abstract |
Tuberculosis (TB) is caused by the Mycobacterium tuberculosis complex (MTBC), a wildly successful group of organisms and the leading cause of death resulting from a single bacterial pathogen worldwide. It is generally accepted that MTBC established itself in human populations in Africa and that animal-infecting strains diverged from human strains. However, the precise causal factors of TB emergence remain unknown. Here, we propose that the advent of controlled fire use in early humans created the ideal conditions for the emergence of TB as a transmissible disease. This hypothesis is supported by mathematical modeling together with a synthesis of evidence from epidemiology, evolutionary genetics, and paleoanthropology. Language: en |