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Citation
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Ji C, Li Y, Cui L, Cai J, Shi J, Cheng FW, Li Y, Curhan GC, Wu S, Gao X. Arthritis Care Res. (2010) 2016; 69(5): 703-708. |
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Abstract
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OBJECTIVE: To test whether prenatal earthquake exposure (as a surrogate for acute prenatal stress) could have unfavorable effects on uric acid status in later life.
METHODS: We included 536 individuals who had been prenatally exposed to the Tangshan earthquake in 1976, and 536 sex- and age-matched individuals without this exposure. Serum uric acid concentrations were measured based on fasting blood samples which were repeatedly collected in 2006, 2008, and 2010. Mean uric acid concentrations in 2010 and the increasing rate from 2006 to 2010, between two groups, were compared after adjustment for age, sex, body mass index, serum concentrations of glucose, triglyceride, C-reactive protein, estimated glomerular filtration rate and other potential confounders. We also used multiple logistic regression to estimate the risk of hyperuricemia (> 416 μmol/L in men or > 357 μmol/L in women) in 2010 by calculating the odds ratios (ORs) and 95% confidence intervals(CIs) after adjustment for aforementioned covariates.
RESULTS: Participants with prenatal exposure to the earthquake had higher concentrations of serum uric acid (adjusted means: 315 vs 296 µmol/L, p=0.002) and higher likelihood of having hyperuricemia (multivariate adjusted OR=1.70; 95% CI 1.09-2.66) in 2010 relative to those without the exposure. Consistently, prenatal exposure to the earthquake was significantly associated with a faster increase in uric acid concentrations from 2006 to 2010 (P<0.001).
CONCLUSION: Exposure to prenatal earthquake was associated with higher serum uric acid and higher odds of hyperuricemia in early adulthood. This article is protected by copyright. All rights reserved.
© 2016, American College of Rheumatology.
Language: en |