Citation

Brundin L, Bryleva EY, Rajamani KT. Neuropsychopharmacology 2016; 42(1): 271-283.

Affiliation

Laboratory of Behavioral Medicine, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, USA.

Copyright

(Copyright © 2016, Nature Publishing Group)

DOI

10.1038/npp.2016.116

PMID

27377015

Abstract

Suicidal behavior is complex and manifests because of a confluence of diverse factors. One such factor involves dysregulation of the immune system, which has been linked to the pathophysiology of suicidal behavior. This review will provide a brief description of suicidality and discuss the contribution of upstream and downstream factors in the etiology of suicidal behavior, within the contextual framework of inflammation. The contribution of inflammatory conditions such as traumatic brain injury, autoimmune disorders, and infections to neuropsychiatric symptoms and suicidality is only beginning to be explored. We will summarize studies of inflammation in the etiology of suicide, and provide a neurobiological basis for different mechanisms by which inflammation might contribute to the pathophysiology. Finally, we will review treatments that affect upstream and downstream pathways related to inflammation in suicidality.Neuropsychopharmacology accepted article preview online, 05 July 2016. doi:10.1038/npp.2016.116.

Language: en