Citation

Krishna AB, Manikyam HK, Sharma VK, Sharma N. Fundam. Toxicol. Sci. 2016; 3(1): 9-12.

Copyright

(Copyright © 2016, Japanese Society of Toxicology)

DOI

10.2131/fts.3.9

PMID

unavailable

Abstract

Picrorhiza kurroa is a well-known ayurvedic or herbal medicine which is used very commonly in the treatment of various diseases. Therefore, we studied the oral toxicity of Picrorhiza kurroa rhizome extract in rats. A single high dose of the extract at 2000 mg/kg body weight was tested on Wistar rats. Mortality/viability and clinical signs were recorded on test day 0 (prior to administration), 7, 14 and at death. All animals appeared normal from day one to throughout the experimental procedure. Picrorhiza kurroa rhizome extract is non-toxic to rats and helped in weight gain with LD50 > 2000 mg/kg body weight. Oral administration of Picrorhiza kurroa is not connected with any toxicologically significant effects and the data could provide satisfactory preclinical evidence of safety to launch a clinical trial on a standardized formulation of the plant extracts.

Language: en