Citation

Baud FJ, Houze P, Villa A, Borron SW, Carli P. Ann. Pharm. Fr. 2016; 74(3): 173-189.

Affiliation

Département d'anesthésie-réanimation, SAMU 75, réanimation adulte polyvalente, groupe hospitalier Necker, Assistance publique-Hôpitaux de Paris, 75015 Paris, France.

Copyright

(Copyright © 2016, Elsevier Publishing)

DOI

10.1016/j.pharma.2016.02.003

PMID

27107462

Abstract

OBJECTIVES: Regarding the different disciplines that encompass the pharmacology and the toxicology, none is specifically dedicated to the description and analysis of the time-course of relevant toxic effects both in experimental and clinical studies. The lack of a discipline devoted to this major field in toxicology results in misconception and even in errors by clinicians. MATERIAL AND METHODS: Review of the basic different disciplines that encompass pharmacology toxicology and comparing with the description of the time-course of effects in conditions in which toxicological analysis was not performed or with limited analytical evidence.

RESULTS: Review of the literature clearly shows how misleading is the current extrapolation of toxicokinetic data to the description of the time-course of toxic effects.

CONCLUSION: A new discipline entitled toxicodynetics should be developed aiming at a more systematic description of the time-course of effects in acute human and experimental poisonings. Toxicodynetics might help emergency physicians in risk assessment when facing a poisoning and contribute to a better assessment of quality control of data collected by poison control centres. Toxicodynetics would also allow a quantitative approach to the clinical effects resulting from drug-drug interaction.

Copyright © 2016. Published by Elsevier Masson SAS.

Language: en