Citation

Zander NE, Piehler T, Banton R, Boggs M. Anal. Biochem. 2016; 504: 4-6.

Affiliation

Department of Biology, University of Delaware, Newark DE 19716.

Copyright

(Copyright © 2016, Elsevier Publishing)

DOI

10.1016/j.ab.2016.03.009

PMID

27033003

Abstract

Diagnosis of mild to moderate traumatic brain injury is challenging because brain tissue damage progresses slowly and is not readily detectable by conventional imaging techniques. We have developed a novel in vitro model to study primary blast loading on dissociated neurons using nitroamine explosives such as those used on the battlefield. Human neuroblastoma cells were exposed to single and triple 50-psi explosive blasts and single 100-psi blasts. Changes in membrane permeability and oxidative stress showed a significant increase for the single and triple 100-psi blast conditions compared with single 50-psi blast and controls.

Copyright © 2016. Published by Elsevier Inc.

Language: en