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Citation
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Hyodoh H, Terashima R, Rokukawa M, Shimizu J, Okazaki S, Mizuo K, Watanabe S. Leg. Med. (Elsevier) 2016; 19: 11-15. |
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Abstract
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PURPOSE: Experimental drowning models were prepared to investigate the time-related course of lung changes using postmortem CT. This study was approved by our institutional animal ethics committee.
MATERIALS AND METHODS: Fifteen NZW rabbits (female fifteen, 2.6-4.3 (mean 3.3)kg) were divided into 3 groups: fresh water drowning (FRESH), sea water drowning (SEA), and sea water drowning with anterior chest compression (ACC). All individuals were examined by CT (Aquilion CX, Toshiba, Japan) on postmortem time course. The rabbit's head was submerged in a water bath for a total of 10min. In ACC, cardiopulmonary resuscitation was performed for 2min, additionally. The percentage of aerated lung volumes (%ALV=100 (aerated lung volume/total lung volume)) were statistically evaluated and the lung CT image patterns and pleural fluid appearance time were investigated.
RESULTS: All lungs had decreased their %ALV within 24h, and there were no statistical differences in and among the 3 groups. After 36h, %ALV tended to increase in all groups, and only ACC presented a statistical difference between 1h and 36h (p<0.005). On postmortem lung CT, all lungs presented ground-glass opacity with interstitial thickening spread pattern (100%) and no pattern change during the follow-up period. After presenting pleural space fluid collection, the %ALV tended to increase.
CONCLUSION: There were no differences among FRESH, SEA, and ACC in %ALV within 24h. Only ground-glass opacity could be detected on postmortem lung CT, experimentally.
Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
Language: en |