Citation

Erenler AK, Doğan T, Koçak C, Ece Y. Basic Clin. Pharmacol. Toxicol. 2016; 119(3): 317-321.

Affiliation

Hitit University, Çorum Education and Research Hospital, Department of Emergency Medicine, Çorum, Turkey.

Copyright

(Copyright © 2016, Nordic Pharmacological Society, Publisher John Wiley and Sons)

DOI

10.1111/bcpt.12569

PMID

26879235

Abstract

Mushroom poisoning (MP) is a public health problem in many countries. It is well-known that consumption of wild mushrooms may cause serious toxicity on renal, hepatic and brain functions. In the literature, however, studies investigating cardiotoxic effects of MP are rare. In this study, we evaluated laboratory and ECG findings of patients and sought for possible toxic effects of MP on the cardiovascular system. During a 2-year period, 175 patients with MP were included in the study. The majority of the poisonings occurred in early summertime. The most common complaint was found to be nausea and vomiting followed by mental status alterations.

METHODS of treatment were mainly based on gastric lavage, activated charcoal and supportive therapy. The most common ECG abnormalities in the patients with MP were sinus tachycardia, sinus arrhythmia, ST/T inversion, 1(st) degree AV block and QT prolongation, respectively. Cardiac markers of the patients were found to be normal. Then, patients were divided into two subgroups according to symptom onset after consumption (less than 6 hr and more than 6 hr). When the two groups were compared, prevalence of tachycardia was significantly higher in Group II. Additionally, a correlation between interval between mushroom consumption and onset of symptoms was strongly correlated with blood pressure (BP). As this interval prolonged, BP of the patients tended to increase. In conclusion, according to our results, although mechanisms need to be clarified, MP causes hypertension and ECG alterations, particularly tachycardia in patients with late-onset symptoms. This article is protected by copyright. All rights reserved.

Language: en