Citation

Lu DY, Zhu PP, Lu TR, Che JY. Cent. Nerv. Syst. Agents Med. Chem. 2016; 16(3): 231-239.

Affiliation

Shanghai University, Shanghai 200444, PR China. ludayong@shu.edu.cn.

Copyright

(Copyright © 2016, Bentham Science Publishers)

DOI

unavailable

PMID

26861554

Abstract

Suicide events and episodes are serious human psychiatric disorders affected by a great number of different environmental/economic factors, early trauma/abuse, human bad living habits, human genomic properties and drug intervention decisions. In order to improve antidepressant therapeutics in clinics, the relationships between efficacy and toxicities of antidepressants have to be considered fundamentally. Since the occurrences and risks of suicidal events or episodes come from interplay between insiders (chemical/genomic/bioinformatics factors) and outsiders (economic/social/previous trauma conditions and so on), new perspectives and scientific studies must be implemented for revealing these interrelated factors step-by-step and update therapeutics in individual human beings. New paradigms and clinical strategies -joint-expert groups and clinical practices (a psychiatrist with other field specialists) should be established for individual patients in future. Thus can some improvements in clinical trials be achieved in a long run?

Language: en