Citation

Yamazaki H, Tajima S, Takeuchi T. Int. J. Clin. Exp. Med. 2015; 8(9): 16863-16867.

Affiliation

Department of Hematology, Shizuoka Saiseikai General Hospital Shizuoka, Japan.

Copyright

(Copyright © 2015, e-Century Publishing)

DOI

unavailable

PMID

26629236

PMCID

PMC4659124

Abstract

Ethyl methanesulfonate is a mutagenic, alkylating agent and considered harmful to humans at levels greater than a certain threshold; however, the toxicity at high doses remains unclear. We report a case of a Japanese man who presented with status epilepticus, rhabdomyolysis, pancytopenia, and hair loss after accidental ingestion of a massive amount of ethyl methanesulfonate. The patient completely recovered with critical care, including multiple antiepileptic drugs, renal replacement therapy, blood transfusion, granulocyte colony-stimulating factor therapy, and antibacterial/fungal prophylaxis. The case indicates that ethyl methanesulfonate causes neurotoxicity, hepatotoxicity, hematotoxicity, and renal toxicity, which can be successfully treated with appropriate palliative therapies.

Language: en